For S.T.A.L.K.E.R. 2, GSC Game World announced the final PC requirements for different settings. At minimum, the game requires an Intel Core i7-7700K processor, a GTX 1060 (6GB), and 16GB of RAM to run at 1080p with low settings at 30 fps.

For a smoother experience at 1080p and 60 fps on medium settings, an Intel Core i7-9700K processor and an RTX 2070 Super or RTX 4060 are recommended.

Achieving high settings at 1440p and 60 fps will need an Intel Core i7-11700 processor, RTX 3070 Ti, and 32GB of RAM. The top-tier experience, with "epic" graphics settings at 4K and over 60 fps, requires an Intel Core i7-13700KF processor, RTX 4080, and 32GB of RAM.

The game demands approximately 160GB of space on an SSD for optimal performance.